凯利风湿病学

出版时间：2002-8  出版社：人民卫生出版社  作者：路迪  页数：1788  字数：5234000  

内容概要

More than 20 years ago, in the preface to the first edition of the Textbook of Rheumatology, we suggested that "The field of rheumatology has come of age." What we meant was that rheumatology had shed its strictly empirical base and its host of unproven remedies and become a healing discipline thoroughly grounded in science. We thought it was time for a new textbook, one that reflected this passage through epistemological puberty.     The sixth edition reflects the maturation of rheumatology as a subspecialty. It is instructive to compare the contents of the first and sixth editions. Many chapters have disappeared entirely, and their material has been condensed and incorporated into existing chapters. Consider, for example, that in the basic science section of the first edition we devoted entire chapters to immunoglobulin structure, the contact activation system, and lysosomes (not to mention purine metabolism, a subject dear to the heart of the then senior editor). Cyclic nucleotides and eosinophilic chemotactic factor of anaphylaxis figured prominently in the titles of other basic science chapters. None of these has a place in the Table of Contents of the current edition. Instead, there are chapters dealing with dendritic cells, leukotrienes, mast cells, nitric oxide, fibroblasts, cytokines, and apoptosis. The importance of these topics to understanding the rheumatic diseases was unknown 20 years ago, and some of them hadn't even been discovered! Who can imagine what the scientific basis of rheumatology will be in the 10th edition, 20 years from now? Surely, knowledge obtained from the working through of the human genome will figure prominently.

书籍目录

VOLUME 1  Section 1 BIOLOGY OF THE NORMAL JOINT    1. BIOLOGY OF THE NORMAL JOINT    2. COLLAGEN AND ELASTIN    3. MATRIX GLYCOPROTEINS,PROTEOGLYCANS,AND CARTILAGE    4. PROTEINASES AND MATRIX DEGRADATION    5. BIOMECHANICS OF JOINTS  Section 2 IMMUNE AND INFLAMMATORY RESPONSES    6. MACROPHAGES,DENDRITIC CELLS,AND FOLLICULAR DENDRITIC CELLS    7. GENETICS OF RHEUMATIC DISEASES    8. T LYMPHOCYTES    9. B CELLS    10. RHEUMATOID FACTOR    11. ANTINUCLEAR ANTIBODIES    12. IMMUNE COMPLEXES    13. COMPLEMENT    14. NEUTROPHILS AND EOSINOPHILS    15. PROSTAGLANDINS,LEUKOTRIENES,AND RELATED COMPOUNDS    16. THE MAST CELL    17. ENDOTHELIAL CELLS AND NITRIC OXIDE    18. PLATELETS    19. FIBROBLAST FUNCTION AND FIBROSIS    20. CYTOKINES    21. APOPTOSIS    22. AUTOMMUNITY  Section 3 EVALUATION OF THE PATIENT    23. EPIDEMIOLOGY OF THE RHEUMATIC DISEASES    24. EVIDENCE-BASED RHEUMATOLOGY    25. EXAMINATION OF THE JOINTS    26. MONARTICULAR ARTHRITIS    27. POLYARTICULAR ARTHRITIS    28. WEAKNESS    29. THE EYE AND RHEUMATIC DISEASE    30. THE SKIN  Section 4 MUSCULOSKELETAL PAIN AND EVALUATION    31. FIBROMYALGIA    32. OCCUPATIONAL AND RECREATIONAL MUSCULOSKELETAL DISORDERS    33. SPORTS MEDICINE    34. NECK PAIN    35. SHOULDER PAIN    36. LOW BACK PAIN    37. HIP AND KNEE PAIN    38. ANKLE AND FOOT PAIN    39. TEMPOROMANDIBULAR JOINT PAIN    40. HAND AND WRIST PAIN  Section 5 DIAGNOSTIC TESTS AND PROCEDURES    41. ASPIRATION AND INJECTION OF JOINTS AND SOFT TISSUES    42. SYNOVIAL FLUID ANALYSIS AND SYNOVIAL BIOPSY    43. IMAGING    44. ARTHROSCOPY AND SYNOVECTOMY    45. LABORATORY EVALUATION OF INFLAMMATION    46. BIOLOGIC MARKERS  Section 6 SPECIAL ISSUES    47. NUTRITION AND RHEUMATIC DISEASES    48. PSYCHOSOCIAL MANAGEMENT OF RHEUMATIC DISEASES    49. GERIATRICS AND THE RHEUMATIC DISEASES    50. ALTERNATIVE CARE FOR ARTHRITIS AND RELATED MUSCULOSKELETAL DISEASES    51. CHRONIC PAIN MANAGEMENT    52. REHABILITATION OF PATIENTS WITH RHEUMATIC DISEASES    53. HEALTH OUTCOME ASSESSMENT  Section 7 CLINICAL PHARMACOLOGY    54. DEVELOPING A CLINICAL TRIAL DESIGN    55. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS    56. GLUCOCORTICOIDS    57. METHOTREXATE    58. SULFASALAZINE    59. ANTIMALARIAL DRUGS    60. GOLD AND PENICILLAMINE    61. IMMUNOREGULATORY DRUGS    62. BIOLOGIC AGENTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS    63. TETRACYCLINES  INDEXVOLUME 2  Section 8 RHEUMATOID ARTHRITIS  Section 9 SPONDYLOARTHROPATHIES  Section 10 SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES  Section 11 VASCULITIC SYNDROMES  Section 12 SCLERODERMA AND MIXED CONNECTIVE TISSUE DISEASES  Section 13 STRUCTURE,FUNCTION,AND DISEASE OF MUSCLE  Section 14 RHEUMATIC DISEASES OF CHILDHOOD  Section 15 CRYSTAL-ASSOCIATED SYNOVITIS  Section 16 OSTEOARTHRITIS,POLYCHONDRITIS,AND HERITABLE DISORDERS  Section 17 ARTHRITIS RELATED TO INFECTION  Section 18 ARTHRITIS ACCOMPANYING SYSTEMIC DISORDERS  Section 19 DISORDERS OF BONE AND STRUCTURAL PROTEIN  Section 20 TUMORS INVOLVING JOINTS  Section 21 RECONSTRUCTIVE SURGERY FOR RHEUMATIC DISEASE  INDEX